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Single‐ and multiple‐dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects
AIMS: To characterize the pharmacokinetics, pharmacodynamics and safety of esaxerenone, a mineralocorticoid receptor antagonist, in healthy adult Japanese men. METHODS: Double‐blind, placebo‐controlled, sequential, dose‐escalation studies were conducted in subjects randomized to receive oral once‐da...
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| Publicado no: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6046505/ https://ncbi.nlm.nih.gov/pubmed/29688582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13616 |
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