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Single‐ and multiple‐dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects

AIMS: To characterize the pharmacokinetics, pharmacodynamics and safety of esaxerenone, a mineralocorticoid receptor antagonist, in healthy adult Japanese men. METHODS: Double‐blind, placebo‐controlled, sequential, dose‐escalation studies were conducted in subjects randomized to receive oral once‐da...

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書目詳細資料
發表在:Br J Clin Pharmacol
Main Authors: Kato, Manabu, Furuie, Hidetoshi, Shimizu, Takako, Miyazaki, Atsuhiro, Kobayashi, Fumiaki, Ishizuka, Hitoshi
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046505/
https://ncbi.nlm.nih.gov/pubmed/29688582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13616
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