Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

BACKGROUND: This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological differences. METHODS: A PBPK mo...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Rashid, Memoona, Sarfraz, Muhammad, Arafat, Mosab, Hussain, Amjad, Abbas, Nasir, Sadiq, Muhammad Waqas, Rasool, Muhammad Fawad, Bukhari, Nadeem Irfan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7389632/
https://ncbi.nlm.nih.gov/pubmed/32727574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-020-00429-y
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