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Development and In Vitro Evaluation of Controlled Release Viagra(®) Containing Poloxamer-188 Using Gastroplus(™) PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments

Sildenafil is the active substance in Viagra(®) tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this study focused on an oral controlled release matrix system with the aim to i...

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Dettagli Bibliografici
Pubblicato in:Pharmaceuticals (Basel)
Autori principali: Arafat, Mosab, Sarfraz, Muhammad, AbuRuz, Salahdein
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158482/
https://ncbi.nlm.nih.gov/pubmed/34070160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14050479
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