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Development and In Vitro Evaluation of Controlled Release Viagra(®) Containing Poloxamer-188 Using Gastroplus(™) PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments
Sildenafil is the active substance in Viagra(®) tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this study focused on an oral controlled release matrix system with the aim to i...
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| Udgivet i: | Pharmaceuticals (Basel) |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8158482/ https://ncbi.nlm.nih.gov/pubmed/34070160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14050479 |
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