Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach

PURPOSE: A differential release fixed dose matrix tablet of amlodipine besylate (AML-B) and simvastatin (SIM) was formulated to enhance patient compliance. MATERIAL AND METHOD: In the first phase, release controlling parameters of AML-B and SIM granules were identified and in the second phase a fixe...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Kanwal, Ummarah, Mukhtar, Shahid, Waheed, Muzzamil, Mehreen, Arifa, Abbas, Nasir, Shamim, Rahat, Hussain, Khalid, Rasool, Fatima, Hussain, Amjad, Bukhari, Nadeem Irfan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8164448/
https://ncbi.nlm.nih.gov/pubmed/34079222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S240506
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