Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients

AIM: The study was aimed to understand the underlying causes for the differences in propranolol pharmacokinetics (PK) between healthy and cirrhosis populations by using a systematic whole-body physiologically based pharmacokinetic (PBPK) model-building approach for suggesting model informed proprano...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Kalam, Muhammad Nasir, Rasool, Muhammad Fawad, Alqahtani, Faleh, Imran, Imran, Rehman, Asim Ur, Ahmed, Naveed
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982780/
https://ncbi.nlm.nih.gov/pubmed/33762817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S297981
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