Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression

BACKGROUND: Tumor heterogeneity underlies resistance and disease progression in glioblastoma (GBM), and tumors most commonly recur adjacent to the surgical resection margins in contrast non-enhancing (NE) regions. To date, no targeted therapies have meaningfully altered overall patient survival in t...

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Detalhes bibliográficos
Publicado no:Neurooncol Adv
Main Authors: Blomquist, Mylan R, Ensign, Shannon Fortin, D’Angelo, Fulvio, Phillips, Joanna J, Ceccarelli, Michele, Peng, Sen, Halperin, Rebecca F, Caruso, Francesca P, Garofano, Luciano, Byron, Sara A, Liang, Winnie S, Craig, David W, Carpten, John D, Prados, Michael D, Trent, Jeffrey M, Berens, Michael E, Iavarone, Antonio, Dhruv, Harshil, Tran, Nhan L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388612/
https://ncbi.nlm.nih.gov/pubmed/32743548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa078
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