SGEF is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide

Glioblastoma (GB) is the highest grade and most common form of primary adult brain tumors. Despite surgical removal followed by concomitant radiation and chemotherapy with the alkylating agent temozolomide (TMZ), GB tumors develop treatment resistance and ultimately recur. Impaired response to treat...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Fortin Ensign, Shannon P., Roos, Alison, Mathews, Ian T., Dhruv, Harshil D., Tuncali, Serdar, Sarkaria, Jann N., Symons, Marc H., Loftus, Joseph C., Berens, Michael E., Tran, Nhan L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794363/
https://ncbi.nlm.nih.gov/pubmed/26764186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0183
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