Calcilytic NPS2143 promotes proliferation and inhibits apoptosis of spontaneously hypertensive rat vascular smooth muscle cells via activation of the renin-angiotensin system

Vascular smooth muscle cell (VSMC) proliferation and apoptosis and the renin-angiotensin system (RAS) play critical roles in the development of essential hypertension. The activation of calcium-sensing receptor (CaSR), functionally expressed in VSMCs, inhibits cyclic adenosine monophosphate (cAMP) f...

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Pubblicato in:Exp Ther Med
Autori principali: Zhao, Yongli, Tang, Na, Xi, Dongmei, Huang, Zhen, Zhang, Tian, Liu, Yongmin, Wang, Lamei, Tang, Yan, Zhong, Hua, He, Fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388331/
https://ncbi.nlm.nih.gov/pubmed/32742325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2020.8759
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