The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca(2+) channels

The present study investigates the effect of commonly used negative and positive allosteric modulators of the calcium-sensing receptor (CaSR) on vascular reactivity. In wire myography studies, increasing [Ca(2+)](o) from 1 mM to 6 mM induced concentration-dependent relaxations of methoxamine-induced...

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Detalles Bibliográficos
Publicado en:Eur J Pharmacol
Main Authors: Greenberg, Harry Z.E., Jahan, Kazi S., Shi, Jian, Vanessa Ho, W.-S., Albert, Anthony P.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science 2016
Assuntos:
Cardiovascular Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127511/
https://ncbi.nlm.nih.gov/pubmed/27725162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2016.10.008
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