Non-canonical mTORC2 signaling regulates brown adipocyte lipid catabolism through SIRT6-FoxO1

mTORC2 controls glucose and lipid metabolism, but the mechanisms have been unclear. Here, we show that conditionally deleting the essential mTORC2 subunit Rictor in murine brown adipocytes inhibits de novo lipid synthesis, promotes lipid catabolism and thermogenesis, and protects against diet-induce...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell
Prif Awduron: Jung, Su Myung, Hung, Chien-Min, Hildebrand, Samuel R., Sanchez-Gurmaches, Juan, Martinez-Pastor, Barbara, Gengatharan, Jivani M., Wallace, Martina, Mukhopadhyay, Dimpi, Calejman, Camila Martinez, Luciano, Amelia K., Hsiao, Wen-Yu, Tang, Yuefeng, Li, Huawei, Daniels, Danette L., Mostoslavsky, Raul, Metallo, Christian M., Guertin, David A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388077/
https://ncbi.nlm.nih.gov/pubmed/31442424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.023
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