Non-canonical mTORC2 signaling regulates brown adipocyte lipid catabolism through SIRT6-FoxO1

mTORC2 controls glucose and lipid metabolism, but the mechanisms have been unclear. Here, we show that conditionally deleting the essential mTORC2 subunit Rictor in murine brown adipocytes inhibits de novo lipid synthesis, promotes lipid catabolism and thermogenesis, and protects against diet-induce...

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Pubblicato in:Mol Cell
Autori principali: Jung, Su Myung, Hung, Chien-Min, Hildebrand, Samuel R., Sanchez-Gurmaches, Juan, Martinez-Pastor, Barbara, Gengatharan, Jivani M., Wallace, Martina, Mukhopadhyay, Dimpi, Calejman, Camila Martinez, Luciano, Amelia K., Hsiao, Wen-Yu, Tang, Yuefeng, Li, Huawei, Daniels, Danette L., Mostoslavsky, Raul, Metallo, Christian M., Guertin, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7388077/
https://ncbi.nlm.nih.gov/pubmed/31442424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.023
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