Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis

The enhanced intracellular survival (Eis) protein of Mycobacterium tuberculosis (Mtb) is a versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their binding to the bacterial ribosome. When overexpressed as a result of promoter mutations, Eis causes drug resistance....

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Gepubliceerd in:ACS Chem Biol
Hoofdauteurs: Punetha, Ankita, Ngo, Huy X., Holbrook, Selina Y. L., Green, Keith D., Willby, Melisa J., Bonnett, Shilah A., Krieger, Kyle, Dennis, Emily K., Posey, James E., Parish, Tanya, Tsodikov, Oleg V., Garneau-Tsodikova, Sylvie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385556/
https://ncbi.nlm.nih.gov/pubmed/32421305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00184
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