Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors

Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identification of highly effective antitubercular drugs with novel modes of action is crucial. In this paper, we report the discovery and development of pyrrolo[1,5-a]pyrazine-based analogues as highly potent inhi...

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Foilsithe in:ACS Infect Dis
Main Authors: Garzan, Atefeh, Willby, Melisa J., Ngo, Huy X., Gajadeera, Chathurada S., Green, Keith D., Holbrook, Selina Y. L., Hou, Caixia, Posey, James E., Tsodikov, Oleg V., Garneau-Tsodikova, Sylvie
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971065/
https://ncbi.nlm.nih.gov/pubmed/28192916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00193
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