Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors

Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identification of highly effective antitubercular drugs with novel modes of action is crucial. In this paper, we report the discovery and development of pyrrolo[1,5-a]pyrazine-based analogues as highly potent inhi...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Garzan, Atefeh, Willby, Melisa J., Ngo, Huy X., Gajadeera, Chathurada S., Green, Keith D., Holbrook, Selina Y. L., Hou, Caixia, Posey, James E., Tsodikov, Oleg V., Garneau-Tsodikova, Sylvie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5971065/
https://ncbi.nlm.nih.gov/pubmed/28192916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00193
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