Tyrosine kinase inhibitors induce alternative spliced BCR‐ABL (Ins35bp) variant via inhibition of RNA polymerase II on genomic BCR‐ABL

To elucidate dynamic changes in native BCR‐ABL and alternatively spliced tyrosine kinase inhibitor (TKI)‐resistant but function‐dead BCR‐ABL(Ins35bp) variant, following commencement or discontinuation of TKI therapy, each transcript was serially quantified in patients with chronic myeloid leukemia (...

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Publicado en:Cancer Sci
Autores principales: Yuda, Junichiro, Odawara, Jun, Minami, Mariko, Muta, Tsuyoshi, Kohno, Kentaro, Tanimoto, Kazuki, Eto, Tetsuya, Shima, Takahiro, Kikushige, Yoshikane, Kato, Koji, Takenaka, Katsuto, Iwasaki, Hiromi, Minami, Yosuke, Ohkawa, Yasuyuki, Akashi, Koichi, Miyamoto, Toshihiro
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385367/
https://ncbi.nlm.nih.gov/pubmed/32314454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14424
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