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Amides as Bioisosteres of Triazole-Based Geranylgeranyl Diphosphate Synthase Inhibitors

Geranylgeranyl diphosphate synthase (GGDPS) inhibitors are of potential therapeutic interest as a consequence of their activity against the bone marrow cancer multiple myeloma. A series of bisphosphonates linked to an isoprenoid tail through an amide linkage has been prepared and tested for the abil...

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發表在:Bioorg Med Chem
Main Authors: Goetz, Daniel B., Varney, Michelle L., Wiemer, David F., Holstein, Sarah A.
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384665/
https://ncbi.nlm.nih.gov/pubmed/32690260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115604
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