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A New Motif for Inhibitors of Geranylgeranyl Diphosphate Synthase
The enzyme geranylgeranyl diphosphate synthase (GGDPS) is believed to receive the substrate farnesyl diphosphate through one lipophilic channel and release the product geranylgeranyl diphosphate through another. Bisphosphonates with two isoprenoid chains positioned on the α-carbon have proven to be...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4955788/ https://ncbi.nlm.nih.gov/pubmed/27338660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.06.019 |
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