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A New Motif for Inhibitors of Geranylgeranyl Diphosphate Synthase

The enzyme geranylgeranyl diphosphate synthase (GGDPS) is believed to receive the substrate farnesyl diphosphate through one lipophilic channel and release the product geranylgeranyl diphosphate through another. Bisphosphonates with two isoprenoid chains positioned on the α-carbon have proven to be...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem
Main Authors: Foust, Benjamin J., Allen, Cheryl, Holstein, Sarah A., Wiemer, David F.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955788/
https://ncbi.nlm.nih.gov/pubmed/27338660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.06.019
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