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Cell-based ligand discovery for the ENL YEATS domain
ENL is a transcriptional co-activator that recruits elongation machinery to active cis-regulatory elements upon binding of its YEATS domain – a chromatin reader module – to acylated lysine side chains. Discovery chemistry for the ENL YEATS domain is highly motivated by its significance in acute leuk...
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| Publicado no: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7384521/ https://ncbi.nlm.nih.gov/pubmed/32176478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00124 |
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