Cell-based ligand discovery for the ENL YEATS domain

ENL is a transcriptional co-activator that recruits elongation machinery to active cis-regulatory elements upon binding of its YEATS domain – a chromatin reader module – to acylated lysine side chains. Discovery chemistry for the ENL YEATS domain is highly motivated by its significance in acute leuk...

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Publicat a:ACS Chem Biol
Autors principals: Asiaban, Joshua N., Milosevich, Natalia, Chen, Emily, Bishop, Timothy R., Wang, Justin, Zhang, Yuxiang, Ackerman, Christopher J., Hampton, Eric, Young, Travis S., Hull, Mitchell, Cravatt, Benjamin F., Erb, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384521/
https://ncbi.nlm.nih.gov/pubmed/32176478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00124
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