Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

[Image: see text] Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic loss-of-function studies have recently implicated the transcriptional coactivator, E...

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Détails bibliographiques
Publié dans:ACS Cent Sci
Auteurs principaux: Garnar-Wortzel, Leopold, Bishop, Timothy R., Kitamura, Seiya, Milosevich, Natalia, Asiaban, Joshua N., Zhang, Xiaoyu, Zheng, Qinheng, Chen, Emily, Ramos, Anissa R., Ackerman, Christopher J., Hampton, Eric N., Chatterjee, Arnab K., Young, Travis S., Hull, Mitchell V., Sharpless, K. Barry, Cravatt, Benjamin F., Wolan, Dennis W., Erb, Michael A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2021
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161486/
https://ncbi.nlm.nih.gov/pubmed/34079898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01550
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