SuFEx-enabled high-throughput medicinal chemistry

Optimization of small-molecule probes or drugs is a lengthy, challenging and resource-intensive process. Lack of automation and reliance on skilled medicinal chemists is cumbersome in both academic and industrial settings. Here, we demonstrate a high-throughput hit-to-lead process based on the bioco...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Kitamura, Seiya, Zheng, Qinheng, Woehl, Jordan L., Solania, Angelo, Chen, Emily, Dillon, Nicholas, Hull, Mitchell V., Kotaniguchi, Miyako, Kitamura, Shinichi, Nizet, Victor, Sharpless, K. Barry, Wolan, Dennis W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751259/
https://ncbi.nlm.nih.gov/pubmed/32479075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b13652
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