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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
Sulfur fluoride exchange (SuFEx) has emerged as the new generation of click chemistry. We report here a SuFEx-enabled, agnostic approach for the discovery and optimization of covalent inhibitors of human neutrophil elastase (hNE). Evaluation of our ever-growing collection of SuFExable compounds towa...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6754619/ https://ncbi.nlm.nih.gov/pubmed/31484779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909972116 |
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