Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

[Image: see text] Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic loss-of-function studies have recently implicated the transcriptional coactivator, E...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Garnar-Wortzel, Leopold, Bishop, Timothy R., Kitamura, Seiya, Milosevich, Natalia, Asiaban, Joshua N., Zhang, Xiaoyu, Zheng, Qinheng, Chen, Emily, Ramos, Anissa R., Ackerman, Christopher J., Hampton, Eric N., Chatterjee, Arnab K., Young, Travis S., Hull, Mitchell V., Sharpless, K. Barry, Cravatt, Benjamin F., Wolan, Dennis W., Erb, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8161486/
https://ncbi.nlm.nih.gov/pubmed/34079898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01550
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