Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity. Versican is produced mainly by adipocytes and biglyca...

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Pubblicato in:Cell Rep
Autori principali: Han, Chang Yeop, Kang, Inkyung, Harten, Ingrid A., Gebe, John A., Chan, Christina K., Omer, Mohamed, Alonge, Kimberly M., den Hartigh, Laura J., Kjerulf, Diego Gomes, Goodspeed, Leela, Subramanian, Savitha, Wang, Shari, Kim, Francis, Birk, David E., Wight, Thomas N., Chait, Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384517/
https://ncbi.nlm.nih.gov/pubmed/32610121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107818
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