Adipocyte-specific deficiency of NADPH oxidase 4 delays the onset of insulin resistance and attenuates adipose tissue inflammation in obesity

OBJECTIVE: Obesity is associated with insulin resistance and adipose tissue inflammation. Reactive oxygen species (ROS) increase in adipose tissue during the development of obesity. We previously showed that in response to excess nutrients like glucose and palmitate, adipocytes generated ROS via NAD...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Den Hartigh, Laura J., Omer, Mohamed, Goodspeed, Leela, Wang, Shari, Wietecha, Tomasz, O’Brien, Kevin D., Han, Chang Yeop
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323321/
https://ncbi.nlm.nih.gov/pubmed/28062496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308749
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