NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes

Excess glucose and free fatty acids delivered to adipose tissue causes local inflammation, which contributes to insulin resistance. Glucose and palmitate generate reactive oxygen species (ROS) in adipocytes, leading to monocyte chemotactic factor gene expression. Docosahexaenoate (DHA) has the oppos...

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Main Authors: Han, Chang Yeop, Umemoto, Tomio, Omer, Mohamed, Den Hartigh, Laura J., Chiba, Tsuyoshi, LeBoeuf, Renee, Buller, Carolyn L., Sweet, Ian R., Pennathur, Subramaniam, Abel, E. Dale, Chait, Alan
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Metabolism
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322984/
https://ncbi.nlm.nih.gov/pubmed/22287546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304998
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