NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes

Excess glucose and free fatty acids delivered to adipose tissue causes local inflammation, which contributes to insulin resistance. Glucose and palmitate generate reactive oxygen species (ROS) in adipocytes, leading to monocyte chemotactic factor gene expression. Docosahexaenoate (DHA) has the oppos...

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Autors principals: Han, Chang Yeop, Umemoto, Tomio, Omer, Mohamed, Den Hartigh, Laura J., Chiba, Tsuyoshi, LeBoeuf, Renee, Buller, Carolyn L., Sweet, Ian R., Pennathur, Subramaniam, Abel, E. Dale, Chait, Alan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322984/
https://ncbi.nlm.nih.gov/pubmed/22287546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304998
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