NADPH Oxidase-derived Reactive Oxygen Species Increases Expression of Monocyte Chemotactic Factor Genes in Cultured Adipocytes

Excess glucose and free fatty acids delivered to adipose tissue causes local inflammation, which contributes to insulin resistance. Glucose and palmitate generate reactive oxygen species (ROS) in adipocytes, leading to monocyte chemotactic factor gene expression. Docosahexaenoate (DHA) has the oppos...

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Hlavní autoři: Han, Chang Yeop, Umemoto, Tomio, Omer, Mohamed, Den Hartigh, Laura J., Chiba, Tsuyoshi, LeBoeuf, Renee, Buller, Carolyn L., Sweet, Ian R., Pennathur, Subramaniam, Abel, E. Dale, Chait, Alan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322984/
https://ncbi.nlm.nih.gov/pubmed/22287546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304998
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