Serum amyloid A–containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties

The ability of HDL to inhibit inflammation in adipocytes and adipose tissue is reduced when HDL contains serum amyloid A (SAA) that is trapped by proteoglycans at the adipocyte surface. Because we recently found that the major extracellular matrix proteoglycan produced by hypertrophic adipocytes is...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Han, Chang Yeop, Kang, Inkyung, Omer, Mohamed, Wang, Shari, Wietecha, Tomasz, Wight, Thomas N., Chait, Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7605543/
https://ncbi.nlm.nih.gov/pubmed/32970631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142635
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