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Dysregulation of the Retromer Complex System in Down Syndrome
OBJECTIVE: Most of the patients with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40. Although this increased susceptibility to AD in DS is thought to be primarily due to triplication of the amyloid precursor protein located on chromosome 21, the precise molecular m...
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| Publicado en: | Ann Neurol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley & Sons, Inc.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7384049/ https://ncbi.nlm.nih.gov/pubmed/32320094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25752 |
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