Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies

Mitochondrial dysfunction has long been implicated in the neurodegenerative disorder Parkinson's disease (PD); however, it is unclear how mitochondrial impairment and α-synuclein pathology are coupled. Using specific mitochondrial inhibitors, EM analysis, and biochemical assays, we report here...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Lautenschläger, Janin, Wagner-Valladolid, Sara, Stephens, Amberley D., Fernández-Villegas, Ana, Hockings, Colin, Mishra, Ajay, Manton, James D., Fantham, Marcus J., Lu, Meng, Rees, Eric J., Kaminski, Clemens F., Kaminski Schierle, Gabriele S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383368/
https://ncbi.nlm.nih.gov/pubmed/32385113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011650
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