TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

The novel emerged SARS-CoV-2 has rapidly spread around the world causing acute infection of the respiratory tract (COVID-19) that can result in severe disease and lethality. For SARS-CoV-2 to enter cells, its surface glycoprotein spike (S) must be cleaved at two different sites by host cell protease...

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Bibliographic Details
Published in:Life Sci Alliance
Main Authors: Bestle, Dorothea, Heindl, Miriam Ruth, Limburg, Hannah, Van Lam van, Thuy, Pilgram, Oliver, Moulton, Hong, Stein, David A, Hardes, Kornelia, Eickmann, Markus, Dolnik, Olga, Rohde, Cornelius, Klenk, Hans-Dieter, Garten, Wolfgang, Steinmetzer, Torsten, Böttcher-Friebertshäuser, Eva
Format: Artigo
Language:Inglês
Published: Life Science Alliance LLC 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7383062/
https://ncbi.nlm.nih.gov/pubmed/32703818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000786
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