TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We previously demonstrated in vitro that the transmembrane protease TMPRSS2 cleaves influenza A virus (IAV) and influenza B virus (IBV) HA possessing a monobasic cleavage site. Subseq...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Limburg, Hannah, Harbig, Anne, Bestle, Dorothea, Stein, David A., Moulton, Hong M., Jaeger, Julia, Janga, Harshavardhan, Hardes, Kornelia, Koepke, Janine, Schulte, Leon, Koczulla, Andreas Rembert, Schmeck, Bernd, Klenk, Hans-Dieter, Böttcher-Friebertshäuser, Eva
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2019
Sujets:
Virus-Cell Interactions
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803253/
https://ncbi.nlm.nih.gov/pubmed/31391268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00649-19
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