TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II Pneumocytes

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We previously demonstrated in vitro that the transmembrane protease TMPRSS2 cleaves influenza A virus (IAV) and influenza B virus (IBV) HA possessing a monobasic cleavage site. Subseq...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Limburg, Hannah, Harbig, Anne, Bestle, Dorothea, Stein, David A., Moulton, Hong M., Jaeger, Julia, Janga, Harshavardhan, Hardes, Kornelia, Koepke, Janine, Schulte, Leon, Koczulla, Andreas Rembert, Schmeck, Bernd, Klenk, Hans-Dieter, Böttcher-Friebertshäuser, Eva
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803253/
https://ncbi.nlm.nih.gov/pubmed/31391268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00649-19
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