Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

APOE4 is a major risk factor for sporadic Alzheimer’s disease; however, it is unclear how it exerts its pathological effects. Others and we have previously shown that autophagy is impaired in APOE4 compared to APOE3 astrocytes, and demonstrated differences in the expression of mitochondrial dynamics...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Schmukler, Eran, Solomon, Shira, Simonovitch, Shira, Goldshmit, Yona, Wolfson, Eya, Michaelson, Daniel Morris, Pinkas-Kramarski, Ronit
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382473/
https://ncbi.nlm.nih.gov/pubmed/32709881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02776-4
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