Continuous treatment with FTS confers resistance to apoptosis and affects autophagy

High percentage of human cancers involves alteration or mutation in Ras proteins, including the most aggressive malignancies, such as lung, colon and pancreatic cancers. FTS (Salirasib) is a farnesylcysteine mimetic, which acts as a functional Ras inhibitor, and was shown to exert anti-tumorigenic e...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Schmukler, Eran, Wolfson, Eya, Elazar, Zvulun, Kloog, Yoel, Pinkas-Kramarski, Ronit
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289601/
https://ncbi.nlm.nih.gov/pubmed/28151959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171351
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items