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Continuous treatment with FTS confers resistance to apoptosis and affects autophagy

High percentage of human cancers involves alteration or mutation in Ras proteins, including the most aggressive malignancies, such as lung, colon and pancreatic cancers. FTS (Salirasib) is a farnesylcysteine mimetic, which acts as a functional Ras inhibitor, and was shown to exert anti-tumorigenic e...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schmukler, Eran, Wolfson, Eya, Elazar, Zvulun, Kloog, Yoel, Pinkas-Kramarski, Ronit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289601/
https://ncbi.nlm.nih.gov/pubmed/28151959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0171351
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