Ras inhibition enhances autophagy, which partially protects cells from death

Autophagy, a process of regulated turnover of cellular constituents, is essential for normal growth control but may be defective under pathological conditions. The Ras/PI3K/mTOR signaling pathway negatively regulates autophagy. Ras signaling has been documented in a large number of human cancers. In...

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Bibliografiske detaljer
Main Authors: Schmukler, Eran, Grinboim, Efrat, Schokoroy, Sari, Amir, Adva, Wolfson, Eya, Kloog, Yoel, Pinkas-Kramarski, Ronit
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702214/
https://ncbi.nlm.nih.gov/pubmed/23370967
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