Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of late-onset, autosomal-dominant familial Parkinson’s disease (PD). LRRK2 functions as both a kinase and GTPase, and PD-linked mutations are known to influence both enzymatic activities. While PD-linked LRRK2 mutations can...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Nguyen, An Phu Tran, Tsika, Elpida, Kelly, Kaela, Levine, Nathan, Chen, Xi, West, Andrew B., Boularand, Sylviane, Barneoud, Pascal, Moore, Darren J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7382283/
https://ncbi.nlm.nih.gov/pubmed/32631998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922184117
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