Conditional Expression of Parkinson's Disease-Related R1441C LRRK2 in Midbrain Dopaminergic Neurons of Mice Causes Nuclear Abnormalities without Neurodegeneration

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heterogeneous. Dominant mutations in LRRK2 p...

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Foilsithe in:Neurobiol Dis
Main Authors: Tsika, Elpida, Kannan, Meghna, Foo, Caroline Shi-Yan, Dikeman, Dustin, Glauser, Liliane, Gellhaar, Sandra, Galter, Dagmar, Knott, Graham W., Dawson, Ted M., Dawson, Valina L., Moore, Darren J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455551/
https://ncbi.nlm.nih.gov/pubmed/25174890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.08.027
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