Conditional Expression of Parkinson's Disease-Related R1441C LRRK2 in Midbrain Dopaminergic Neurons of Mice Causes Nuclear Abnormalities without Neurodegeneration

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heterogeneous. Dominant mutations in LRRK2 p...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neurobiol Dis
Hlavní autoři: Tsika, Elpida, Kannan, Meghna, Foo, Caroline Shi-Yan, Dikeman, Dustin, Glauser, Liliane, Gellhaar, Sandra, Galter, Dagmar, Knott, Graham W., Dawson, Ted M., Dawson, Valina L., Moore, Darren J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4455551/
https://ncbi.nlm.nih.gov/pubmed/25174890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.08.027
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky