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Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells
1,2:5,6-Dianhydrogalactitol (DAG) is a bi-functional DNA-targeting agent currently in phase II clinical trial for treatment of temozolomide-resistant glioblastoma (GBM). In the present study, we investigated the cytotoxic activity of DAG alone or in combination with common chemotherapy agents in GBM...
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| 出版年: | Cell Death Dis |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7381652/ https://ncbi.nlm.nih.gov/pubmed/32709853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02780-8 |
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