Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins

Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here, we present the crystal structure of recombinant Pf...

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Published in:Commun Biol
Main Authors: Singh, Kavita, Burkhardt, Martin, Nakuchima, Sofia, Herrera, Raul, Muratova, Olga, Gittis, Apostolos G., Kelnhofer, Emily, Reiter, Karine, Smelkinson, Margery, Veltri, Daniel, Swihart, Bruce J., Shimp, Richard, Nguyen, Vu, Zhang, Baoshan, MacDonald, Nicholas J., Duffy, Patrick E., Garboczi, David N., Narum, David L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7381611/
https://ncbi.nlm.nih.gov/pubmed/32709983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01123-9
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