Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins

Proteins Pfs230 and Pfs48/45 are Plasmodium falciparum transmission-blocking (TB) vaccine candidates that form a membrane-bound protein complex on gametes. The biological role of Pfs230 or the Pfs230-Pfs48/45 complex remains poorly understood. Here, we present the crystal structure of recombinant Pf...

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Publicado no:Commun Biol
Main Authors: Singh, Kavita, Burkhardt, Martin, Nakuchima, Sofia, Herrera, Raul, Muratova, Olga, Gittis, Apostolos G., Kelnhofer, Emily, Reiter, Karine, Smelkinson, Margery, Veltri, Daniel, Swihart, Bruce J., Shimp, Richard, Nguyen, Vu, Zhang, Baoshan, MacDonald, Nicholas J., Duffy, Patrick E., Garboczi, David N., Narum, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7381611/
https://ncbi.nlm.nih.gov/pubmed/32709983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01123-9
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