Pfs230 yields higher malaria transmission–blocking vaccine activity than Pfs25 in humans but not mice

BACKGROUND: Vaccines that block human-to-mosquito Plasmodium transmission are needed for malaria eradication, and clinical trials have targeted zygote antigen Pfs25 for decades. We reported that a Pfs25 protein-protein conjugate vaccine formulated in alum adjuvant induced serum functional activity i...

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Vydáno v:J Clin Invest
Hlavní autoři: Healy, Sara A., Anderson, Charles, Swihart, Bruce J., Mwakingwe, Agnes, Gabriel, Erin E., Decederfelt, Hope, Hobbs, Charlotte V., Rausch, Kelly M., Zhu, Daming, Muratova, Olga, Herrera, Raul, Scaria, Puthupparampil V., MacDonald, Nicholas J., Lambert, Lynn E., Zaidi, Irfan, Coelho, Camila H., Renn, Jonathan P., Wu, Yimin, Narum, David L., Duffy, Patrick E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8011888/
https://ncbi.nlm.nih.gov/pubmed/33561016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI146221
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