Rare Alleles and Signatures of Selection on the Immunodominant Domains of Pfs230 and Pfs48/45 in Malaria Parasites From Western Kenya

Background: Malaria elimination and eradication efforts can be advanced by including transmission-blocking or reducing vaccines (TBVs) alongside existing interventions. Key transmission-blocking vaccine candidates, such as Pfs230 domain one and Pfs48/45 domain 3, should be genetically stable to avoi...

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Bibliographische Detailangaben
Hauptverfasser: Kevin O. Ochwedo, Fredrick O. Ariri, Wilfred O. Otambo, Edwin O. Magomere, Isaiah Debrah, Shirley A. Onyango, Pauline W. Orondo, Harrysone E. Atieli, Sidney O. Ogolla, Antony C. A. Otieno, Wolfgang R. Mukabana, Andrew K. Githeko, Ming-Chieh Lee, Guiyun Yan, Daibin Zhong, James W. Kazura
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2022-05-01
Schriftenreihe:Frontiers in Genetics
Schlagworte:
Pfs230
Pfs48/45
transmission blocking vaccines
genetic diversity
evolutionary forces
Online Zugang:https://www.frontiersin.org/articles/10.3389/fgene.2022.867906/full
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