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Packing of apolar side chains enables accurate design of highly stable membrane proteins
The features that stabilize the structures of membrane proteins remain poorly understood. Polar interactions contribute modestly, and the hydrophobic effect contributes little to the energetics of apolar side-chain packing in membranes. Disruption of steric packing can destabilize the native folds o...
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| Veröffentlicht in: | Science |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7380683/ https://ncbi.nlm.nih.gov/pubmed/30923216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7541 |
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