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Packing of apolar side chains enables accurate design of highly stable membrane proteins
The features that stabilize the structures of membrane proteins remain poorly understood. Polar interactions contribute modestly, and the hydrophobic effect contributes little to the energetics of apolar side-chain packing in membranes. Disruption of steric packing can destabilize the native folds o...
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| 出版年: | Science |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7380683/ https://ncbi.nlm.nih.gov/pubmed/30923216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7541 |
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