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Packing of apolar side chains enables accurate design of highly stable membrane proteins

The features that stabilize the structures of membrane proteins remain poorly understood. Polar interactions contribute modestly, and the hydrophobic effect contributes little to the energetics of apolar side-chain packing in membranes. Disruption of steric packing can destabilize the native folds o...

詳細記述

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書誌詳細
出版年:Science
主要な著者: Mravic, Marco, Thomaston, Jessica L., Tucker, Maxwell, Solomon, Paige E., Liu, Lijun, DeGrado, William F.
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7380683/
https://ncbi.nlm.nih.gov/pubmed/30923216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav7541
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