Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation

We investigated whether chronic sciatic ligation modifies the glutamate release in spinal cord nerve endings (synaptosomes) as well as the expression and the function of presynaptic release-regulating mGlu2/3 autoreceptors and 5-HT(2A) heteroreceptors in these particles. Synaptosomes were from the s...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Cisani, Francesca, Roggeri, Alessandra, Olivero, Guendalina, Garrone, Beatrice, Tongiani, Serena, Di Giorgio, Francesco Paolo, Pittaluga, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7379891/
https://ncbi.nlm.nih.gov/pubmed/32765286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01108
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