Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation

We investigated whether chronic sciatic ligation modifies the glutamate release in spinal cord nerve endings (synaptosomes) as well as the expression and the function of presynaptic release-regulating mGlu2/3 autoreceptors and 5-HT(2A) heteroreceptors in these particles. Synaptosomes were from the s...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Cisani, Francesca, Roggeri, Alessandra, Olivero, Guendalina, Garrone, Beatrice, Tongiani, Serena, Di Giorgio, Francesco Paolo, Pittaluga, Anna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7379891/
https://ncbi.nlm.nih.gov/pubmed/32765286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01108
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