High throughput screen identifies the DNMT1 inhibitor, 5-azacytidine, as a potent inducer of PTEN: central role for PTEN in 5-azacytidine protection against pathological vascular remodeling

OBJECTIVE –: Our recent work demonstrates that PTEN is an important regulator of SMC phenotype. SMC-specific PTEN deletion promotes spontaneous vascular remodeling and PTEN loss correlates with increased atherosclerotic lesion severity in human coronary arteries. In mice, PTEN overexpression reduces...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Strand, Keith A., Lu, Sizhao, Mutryn, Marie F., Li, Linfeng, Zhou, Qiong, Enyart, Blake T., Jolly, Austin J., Dubner, Allison M., Moulton, Karen S., Nemenoff, Raphael A., Koch, Keith A., LaBarbera, Daniel V., Weiser-Evans, Mary C.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7377968/
https://ncbi.nlm.nih.gov/pubmed/32580634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314458
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