High throughput screen identifies the DNMT1 inhibitor, 5-azacytidine, as a potent inducer of PTEN: central role for PTEN in 5-azacytidine protection against pathological vascular remodeling

OBJECTIVE –: Our recent work demonstrates that PTEN is an important regulator of SMC phenotype. SMC-specific PTEN deletion promotes spontaneous vascular remodeling and PTEN loss correlates with increased atherosclerotic lesion severity in human coronary arteries. In mice, PTEN overexpression reduces...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Strand, Keith A., Lu, Sizhao, Mutryn, Marie F., Li, Linfeng, Zhou, Qiong, Enyart, Blake T., Jolly, Austin J., Dubner, Allison M., Moulton, Karen S., Nemenoff, Raphael A., Koch, Keith A., LaBarbera, Daniel V., Weiser-Evans, Mary C.M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7377968/
https://ncbi.nlm.nih.gov/pubmed/32580634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314458
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker