High throughput screen identifies the DNMT1 inhibitor, 5-azacytidine, as a potent inducer of PTEN: central role for PTEN in 5-azacytidine protection against pathological vascular remodeling

OBJECTIVE –: Our recent work demonstrates that PTEN is an important regulator of SMC phenotype. SMC-specific PTEN deletion promotes spontaneous vascular remodeling and PTEN loss correlates with increased atherosclerotic lesion severity in human coronary arteries. In mice, PTEN overexpression reduces...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Arterioscler Thromb Vasc Biol
Main Authors: Strand, Keith A., Lu, Sizhao, Mutryn, Marie F., Li, Linfeng, Zhou, Qiong, Enyart, Blake T., Jolly, Austin J., Dubner, Allison M., Moulton, Karen S., Nemenoff, Raphael A., Koch, Keith A., LaBarbera, Daniel V., Weiser-Evans, Mary C.M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7377968/
https://ncbi.nlm.nih.gov/pubmed/32580634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314458
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla